CDK Family


Continuous proliferation is an important hallmark of tumor cells, blocking the tumor cell cycle has become an important means to control tumor development. The complex of cyclin and cyclin dependent kinases (CDKs) can control the cell division, and the development of inhibitors around this family has become an important branch of drug development in the field of cancer in recent years.

 

CDKs, belonging to the serine/threonine protein kinase family. CDKs binds to the corresponding regulatory subunit-cyclin to form an active heterodimer, which is mainly involved in cell cycle regulation and transcriptional regulation (Figure 1). CDK1, CDK4, CDK6, etc., involved in the cell cycle include, and CDK7, CDK8, CDK9, etc., involved in transcriptional regulation.

 

Catalog No.

Organism

Expression system

Tag

Sequence

BP468B1-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-M297/N165-V433

BP468A2-21A

Homo sapiens

Insect cell

GST/His

M1-M297/E174-L432

BP468A1-21A

Homo sapiens

Insect cell

GST/His

M1-M297/M1-E410

BP468A2-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-M297/S2-H404

BP469A2-21A

Homo sapiens

Insect cell

GST/His

M1-L298/E174-L432

BP469A1-24A

Homo sapiens

Insect cell

GST/His

M1-L298/M1-E410

BP469A1-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-L298/M1-I295

BP0469O-21A

Homo sapiens

Insect cell

GST/His-Flag

M1-L298/V2-S349

BP469A2-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-L298/S2-H404

BP470A1-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-H305/M1-E410

BP471A2-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-E303/E2-L289

BP498A2-24A

Homo sapiens

Insect cell

GST/His

M1-A326/M1-L292

BP498A1-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-A326/M1-I295

BP487HA-21A

Homo sapiens

Insect cell

GST/His/His

M1-F346/M1-L323/M1-S309

BP475CA-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-Y464/M1-S283/M1-D100

BP0488A-24A

Homo sapiens

Insect cell

GST/His

M1-F372/M1-K726

BP0488A-24A

Homo sapiens

Insect cell

GST/Flag

M1-F372/M1-S300

BP0488A-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-F372/A2-N663

BP0688Y-24A

Homo sapiens

Insect cell

GST/Flag

M1-W435/M1-S341

BP1751Y-24A

Homo sapiens

Insect cell

GST/Flag

M1-F496/M1-S341

BP473CA-24A

Homo sapiens

Insect cell

GST/Flag-His

M1-Y502/M1-S283/M1-D100

 

 

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