COVID-19 Proteins


COVID-19 is one of most severe and contagious virus in human history. Since the outbreak of COVID-19 in 2019, more than 500 million people were infected and it led to over 6 million deaths. Its respiratory infections, long latency period, asymptomatic and prone to mutation properties make it the hardest tractable viruses in recent decades. Based on its strong scientific capacities, Biortus had heavily involved in COVID-19 pathological and drug development studies from the very beginning. Biortus Protein Production Department produced the RdRp enzyme, and Assay & Screening Department studied the inhibitory mechanism of remdesivir developed by Gilead, as shown in figure 1. More recently, Biortus CryoEM Department studied RdRp interaction with compound AT-520, and identified multiple binding sites. The novel discovery suggests that RdRp inhibitor could play more roles than RNA chain termination, figure 2.

 

Biortus

Figure 1. Remdesivir inhibitor effect on RdRp. from W. Yin et al., Science (2020)

Biortus

Figure 2. Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527, from Ashleigh et al., BioRxiv (2021)

 

 

The Biortus Protein Catalogue currently offers all COVID-19 component proteins, with Cryo-EM structurally resolved and specific in-house biochemical assays ready. 

 

Catalog No.

Organism

Expression system

Tag

Sequence

BP06039-01A

Homo sapiens

Insect cell

His

M1-S740

BP06080-01A

SARS-CoV-2

E. coli

His

H13-G128

BP06104-01A

SARS-CoV-2

E. coli

His

A1-Q139

BP06440-02A

SARS-CoV-2

E. coli

GST

A1-Q527

BP06078-01A

SARS-CoV-2

E. coli

His

S1-N298

BP06131-01A

SARS-CoV-2

E. coli

His

A181-G818

BP06148-01A

SARS-CoV-2

E. coli

His

E1-T312

BP06631-02A

SARS-CoV-2

E. coli

GST

N405-Q500

BP06076-01A

SARS-CoV-2

E. coli

His

S1-Q306

BP08401-01A

SARS-CoV-2

E. coli

His

S3831-Q3913

BP08453-14A

SARS-CoV-2

E. coli

His/Flag

A1-Q198

BP06117-01A

SARS-CoV-2

E. coli

His

N4118-Q4230

BP06531-01A

SARS-CoV-2

Insect cell

His/Flag

M1-A419

BP06130-01A

SARS-CoV-2

Insect cell

His

R306-G531

BP11283-13A

SARS-CoV-2

Insect cell

His/Strep

S1-Q932

BP12277-01A

SARS-CoV-2

Mammalian cell

His

M1-Q1208, K986P, V987P

BP06148-01A

2019-nCoV

E. coli

His

E1-T312

 

 

See All Recombinant Proteins >>>
For custom COVID-19 protein generation, please see Protein Generation or contact info@wuxibiortus.com.