PIP4K2B-H00A
Family ：
Kinase
Catalog No. ：
PIP4K2B-H00A
Protein ：
PIP4K2B
UniProt ：
P78356
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
S2-T416
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: PIP4K2B
Alias: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta,1-phosphatidylinositol 5-phosphate 4-kinase 2-beta,Diphosphoinositide kinase 2-beta,Phosphatidylinositol 5-phosphate 4-kinase type II beta,PI(5)P 4-kinase type II beta,PIP4KII-beta,PtdIns(5)P-4-kinase isoform 2-beta
Uniprot: P78356
Background: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9038203, PubMed:26774281). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration (PubMed:26774281). Its GTP-sensing activity is critical for metabolic adaptation (PubMed:26774281). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).
Construct: GG-PIP4K2B(S2-T416 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein