TTK-H04B
Family ：
Kinase
Catalog No. ：
TTK-H04B
Protein ：
TTK
UniProt ：
P33981
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
Flag
Sequence ：
M1-K857, K857G
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: TTK
Alias: Dual specificity protein kinase TTK,Phosphotyrosine picked threonine-protein kinase,PYT
Uniprot: P33981
Background: Phosphorylates proteins on serine, threonine, and tyrosine (PubMed:18243099, PubMed:29162720). Probably associated with cell proliferation (PubMed:18243099). Phosphorylates MAD1L1 to promote mitotic checkpoint signaling (PubMed:29162720). Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (PubMed:18243099).
Construct: TTK (M1-G857)(K857G)-linker-Flag-C
Expression Host: Insect cell
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein