BP13119-41A

Family :

membrane protein

Catalog No. :

BP13119-41A

Protein :

CaSR

UniProt :

P41180

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

Flag,10His

Sequence :

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Product Information

Symbol/Gene Name:  CASR

Alias:  Extracellular calcium-sensing receptor,CaR,CaSR,hCasR,Parathyroid cell calcium-sensing receptor 1,PCaR1

Uniprot: P41180

Background: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).

Construct: HA(signal peptide)-Flag-TEV-CaSR(Y20-S1078 end)-10His

Expression Host: Insect cell

Purity: 80%

Formulation: 20 mM HEPES pH 7.5, 150 mM NaCl, 0.005% GDN, 0.0005% CHS

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Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.