CDK12/Cyclin K-H24A
Family ：
CDK
Catalog No. ：
CDK12/Cyclin K-H24A
Protein ：
CDK12/Cyclin K
UniProt ：
Q9NYV4/O75909
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
GST/Flag
Sequence ：
Q696-S1082/M1-S300
Assay ：
Structure ：
Inquiry ：
是
Product Information
Symbol/Gene Name: CDK12;CCNK
Alias: Cyclin-dependent kinase 12,Cdc2-related kinase, arginine/serine-rich,CrkRS,Cell division cycle 2-related protein kinase 7,CDC2-related protein kinase 7,Cell division protein kinase 12,hCDK12;Cyclin-K
Uniprot: Q9NYV4/O75909
Background: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
;
Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A).
Construct: GST-TEV-CDK12(Q696-S1082)/pFastBac1-FLAG-TEV-Cyclink(1-300)
Expression Host: Insect cell
Purity: 90%
Formulation:
Supplied as sterile 50 mM Tris-HCl (pH 8.0), 200 mM NaCl, 5% glycerol.
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein