CHAC1-H13C
Family ：
Protease and Enzyme
Catalog No. ：
CHAC1-H13C
Protein ：
CHAC1
UniProt ：
Q9BUX1
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
His/Strep
Sequence ：
K2-V222
Assay ：
Structure ：
Inquiry ：
是
Product Information
Symbol/Gene Name: CHAC1
Alias: Glutathione-specific gamma-glutamylcyclotransferase 1,Gamma-GCG 1,Blocks Notch protein,Botch,Cation transport regulator-like protein 1
Uniprot: Q9BUX1
Background: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
Construct: 6His-StrepII-TEV-GG-CHAC1(K2-V222 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein