BP11255-12A

Family :

Kinase

Catalog No. :

BP11255-12A

Protein :

RIOK2

UniProt :

Q9BVS4

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

His/GST

Sequence :

G2-E552

Inquiry :

Symbol/Gene Name:  RIOK2

Alias:  Serine/threonine-protein kinase RIO2,RIO kinase 2

Uniprot: Q9BVS4

Background: Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA (PubMed:19564402). Regulates the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, most likely by PLK1, regulates this function (PubMed:21880710).

Construct: 8His-GST-TEV-GG-RIOK2(G2-E552 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.