RNF113A-H01A
Family ：
E3 ubiquitin-protein ligase
Catalog No. ：
RNF113A-H01A
Protein ：
RNF113A
UniProt ：
O15541
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
His
Sequence ：
A2-T343
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: RNF113A
Alias: E3 ubiquitin-protein ligase RNF113A,Cwc24 homolog,RING finger protein 113A,Zinc finger protein 183
Uniprot: O15541
Background: Required for pre-mRNA splicing as component of the spliceosome (PubMed:29361316, PubMed:29360106). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524).
Construct: 6His-TEV-(GG)-RNF113A(A2-T343 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein