RNF216-H00A
Family ：
E3 ubiquitin-protein ligase
Catalog No. ：
RNF216-H00A
Protein ：
RNF216
UniProt ：
Q9NWF9
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
E2-F866
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: RNF216
Alias: E3 ubiquitin-protein ligase RNF216,RING finger protein 216,RING-type E3 ubiquitin transferase RNF216,Triad domain-containing protein 3,Ubiquitin-conjugating enzyme 7-interacting protein 1,Zinc finger protein inhibiting NF-kappa-B
Uniprot: Q9NWF9
Background: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
Construct: (GG)-RNF216(E2-F866 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein