BP06471-02A

Family :

Kinase

Catalog No. :

BP06471-02A

Protein :

MAP4K6

UniProt :

Q8N4C8

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

GST

Sequence :

M1-G314

Inquiry :

Symbol/Gene Name:  MINK1

Alias:  Misshapen-like kinase 1, GCK family kinase MiNK, MAPK/ERK kinase kinase kinase 6, MEK kinase kinase 6, MEKKK 6, Misshapen/NIK-related kinase,Mitogen-activated protein kinase kinase kinase kinase 6

Uniprot: Q8N4C8

Background: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.

Construct: GST-TEV-MAP4K6(M1-G314)

Expression Host: Insect cell

Purity: 90%

Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.