BP06983-01A

Family :

Virus Protein

Catalog No. :

BP06983-01A

Protein :

NSP5

UniProt :

P0C6U3

Organism :

Human coronavirus HKU1

Expression system :

E. coli

Tag :

His

Sequence :

S3335-V3634

Inquiry :

Symbol/Gene Name:   1a

Alias:  Replicase polyprotein 1a,pp1a,ORF1a polyprotein

Uniprot: P0C6U3

Background: The papain-like proteinase 1 (PL1-PRO) and papain-like proteinase 2 (PL2-PRO) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF-3 (By similarity).

Construct: 6His-TEV-(G)-AS-HKU1-NSP5(S3335-V3634)

Expression Host: E. coli

Purity: 90%

Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol 

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.