BP07829-13A

Family :

SLC

Catalog No. :

BP07829-13A

Protein :

SLC19A1

UniProt :

P41440

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

8His-Strep,Flag

Sequence :

V2-Q591

Inquiry :

Symbol/Gene Name:  SLC19A1

Alias:  Reduced folate transporter,FOLT,Intestinal folate carrier 1,IFC-1,Placental folate transporter,Reduced folate carrier protein,RFC,hRFC,Reduced folate transporter 1,RFT-1,Solute carrier family 19 member 1,hSLC19A1

Uniprot: P41440

Background: Transporter that mediates the import of reduced folates and a subset of cyclic dinucleotides (PubMed:7826387, PubMed:9041240, PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:31126740, PubMed:31511694, PubMed:32276275). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803). Also able to mediate the import of antifolate drug methotrexate (PubMed:7615551, PubMed:7641195, PubMed:9767079, PubMed:22554803). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP (PubMed:31126740, PubMed:31511694). Mechanistically, acts as an antiporter, which export of intracellular organic anions to facilitate uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803).

Construct: 8His-Strep II-TEV-(GG)-SLC19A1 (V2-Q591)-Flag

Expression Host: Insect cell

Purity: 90%

Formulation:

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.