Family :

Virus Protein

Catalog No. :


Protein :


UniProt :


Organism :

Severe acute respiratory syndrome coronavirus 2

Expression system :

E. coli

Tag :


Sequence :


Assay :

Structure :

Inquiry :

Symbol/Gene Name:  ORF8

Alias:  ORF8 protein,ORF8,Non-structural protein 8,ns8

Uniprot: P0DTC8

Background: Plays a role in modulating host immune response (PubMed:31986261). May act by down-regulating major histocompability complex class I (MHC-I) (PubMed:34021074). May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 (PubMed:34177923). Binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors. Contributes to cytokine storm during COVID-19 infection (PubMed:33723527).

Construct: 6His-ORF8(F16-I121)-Flag

Expression Host: E. coli

Purity:  90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol 

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.


< 0.01 EU per μg of the protein


Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.