OTUD5-H14A
Family ：
DUBs
Catalog No. ：
OTUD5-H14A
Protein ：
OTUD5
UniProt ：
Q96G74
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
His/Flag
Sequence ：
G172-G351
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: OTUD5
Alias: OTU domain-containing protein 5,Deubiquitinating enzyme A,DUBA
Uniprot: Q96G74
Background: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931).
Construct: 6His-TEV-GG-OTUD5(G172-G351)-Flag
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein