Family :

E3 ubiquitin-protein ligase

Catalog No. :


Protein :


UniProt :


Organism :

Homo sapiens

Expression system :

Insect cell

Tag :


Sequence :


Assay :

Structure :

Inquiry :

Symbol/Gene Name:  TRIM16

Alias:  Tripartite motif-containing protein 16,E3 ubiquitin-protein ligase TRIM16,Estrogen-responsive B box protein

Uniprot: O95361

Background: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.

Construct: 8His-StrepII-TEV-(GG)-TRIM16(A2-P564 end)

Expression Host: Insect cell

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.


< 0.01 EU per μg of the protein


Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.