5HT1B-H41C
Family ：
GPCR
Catalog No. ：
5HT1B-H41C
Protein ：
5HT1B
UniProt ：
P28222
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
Flag,His
Sequence ：
Inquire for more details
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: HTR1B
Alias: 5-hydroxytryptamine receptor 1B,5-HT-1B,5-HT1B,S12,Serotonin 1D beta receptor,5-HT-1D-beta,Serotonin receptor 1B
Uniprot: P28222
Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Construct: Flag-10His-TEV-5HT1B(N32-I239) (L138W)-BRIL-5HT1B(A306-S390 end)
Expression Host: Insect cell
Purity: 90%
Formulation:
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein