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概要:Compound screening against a drug target whether by high-throughput screening or fragment screening is a vital step in early stage drug discovery. Biortus has an extensive collection of plate readers (detecting UV/light absorbance, fluorescence, luminescence, and scintillation) that allows development of many kinds of biochemical assays including cell-based assays. Coupled with our automated liquid handling machines, we could perform various high-throughput screening (HTS) for our clients. In addition, Biortus currently holds two other specialised screening technologies, Mobility Shift Assays (Caliper EZ Reader II, great for monitoring enzyme reactions) and Surface Plasmon Resonance (SPR, Biacore S200) for fragment screening. Below is a non-exhaustive list of assays performed in Biortus:
概要:Compound screening against a drug target whether by high-throughput screening or fragment screening is a vital step in early stage drug discovery. Biortus has an extensive collection of plate readers (detecting UV/light absorbance, fluorescence, luminescence, and scintillation) that allows development of many kinds of biochemical assays including cell-based assays. Coupled with our automated liquid handling machines, we could perform various high-throughput screening (HTS) for our clients. In addition, Biortus currently holds two other specialised screening technologies, Mobility Shift Assays (Caliper EZ Reader II, great for monitoring enzyme reactions) and Surface Plasmon Resonance (SPR, Biacore S200) for fragment screening. Below is a non-exhaustive list of assays performed in Biortus:
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无论是高通量筛选还是片段筛选,针对药物靶标的化合物筛选都是早期药物发现中的关键步骤。佰翱得拥有多种功能强大的酶标仪,可以检测紫外/可见光吸光度、荧光、化学发光和闪烁发光。以此可开发多种生化分析方法,也可用来做细胞分析。与自动化分液工作站(Aglient Bravo)相互配合,我们还可以为客户提供各种高通量筛选(HTS)服务。 此外,佰翱得目前还拥有两种专业的筛选技术,毛细管电迁移率分析(Caliper EZ Reader II,适用于监测酶反应)和表面等离子体共振分析(SPR,Biacore S200,用于片段筛选)。以下是Biortus的部分分析方法列表:

 

分析方法描述

检测模式

仪器型号

特点

激酶分析

荧光

Caliper EZ Reader II

  • 实时检测,可以做动力学分析
  • 可以用于化合物作用机理研究(MOA)    

ADP-Glo 分析

化学发光

TECAN Infinite F200 Pro/M1000

 

Perkin Elmer Envision 2104

  • 多功能酶标仪可检测 (荧光, 荧光偏振, 时间分辨荧光, 吸光度和化学发光)

镧系金属时间分辨荧光共振分析

时间分辨荧光

荧光偏振分析

荧光偏振

CellTiter-Glo® 化学发光分析

化学发光

MTT 细胞增殖及毒性分析

吸光度

AlphaScreen 分析

荧光

邻近闪烁分析

闪烁荧光

Perkin Elmer TopCount NTX HTS

  • 检测蛋白与蛋白相互作用的理想选择

表面等离子共振分析

光吸收位移

Biacore S200

  • 灵敏度高,可用于片段结合筛选的检测
  • 实时检测分析
  • 提供亲和速率 Kon 和解离速率 Koff

联系我们

联系电话:+86 (510) 8613-0005

公司地址:江苏省江阴市东盛西路6号A5楼

电子邮箱:info@wuxibiortus.com

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